Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through Solubility Enhancement and Precipitation Inhibition

Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. Its pKa is 3.7, which makes it a weak base drug. The aim of this study was to prepare solid dispersion (SD) pellets to enhance the release...

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Detalles Bibliográficos
Autores principales: Lee, Ju-Hyun, Park, Chulhun, Weon, Kwon-Yeon, Kang, Chin-Yang, Lee, Beom-Jin, Park, Jun-Bom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707685/
https://www.ncbi.nlm.nih.gov/pubmed/34959655
http://dx.doi.org/10.3390/ph14121255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707685/
https://www.ncbi.nlm.nih.gov/pubmed/34959655
http://dx.doi.org/10.3390/ph14121255

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