Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats

A combination of the tyrosine kinase inhibitor—sorafenib—and the opioid analgesic—morphine—can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration may affect their pharmacokinetics, and...

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Detalles Bibliográficos
Autores principales: Karbownik, Agnieszka, Szkutnik-Fiedler, Danuta, Grabowski, Tomasz, Wolc, Anna, Stanisławiak-Rudowicz, Joanna, Jaźwiec, Radosław, Grześkowiak, Edmund, Szałek, Edyta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707786/
https://www.ncbi.nlm.nih.gov/pubmed/34959453
http://dx.doi.org/10.3390/pharmaceutics13122172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707786/
https://www.ncbi.nlm.nih.gov/pubmed/34959453
http://dx.doi.org/10.3390/pharmaceutics13122172

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