Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis: A Crystallographic and Molecular Modelling Study

The mycolic acid biosynthetic pathway represents a promising source of pharmacological targets in the fight against tuberculosis. In Mycobacterium tuberculosis, mycolic acids are subject to specific chemical modifications introduced by a set of eight S-adenosylmethionine dependent methyltransferases...

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Detalles Bibliográficos
Autores principales: Galy, Romain, Ballereau, Stéphanie, Génisson, Yves, Mourey, Lionel, Plaquevent, Jean-Christophe, Maveyraud, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708032/
https://www.ncbi.nlm.nih.gov/pubmed/34959681
http://dx.doi.org/10.3390/ph14121282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708032/
https://www.ncbi.nlm.nih.gov/pubmed/34959681
http://dx.doi.org/10.3390/ph14121282

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