Discovery of the First in Class 9-N-Berberine Derivative as Hypoglycemic Agent with Extra-Strong Action

Berberine is well known for its ability to reduce the blood glucose level, but its high effective dose and poor bioavailability limits its use. In this work we synthesized a new derivative of berberine, 9-(hexylamino)-2,3-methylenedioxy-10-methoxyprotoberberine chloride (SHE-196), and analyzed the p...

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Detalles Bibliográficos
Autores principales: Khvostov, Mikhail V., Gladkova, Elizaveta D., Borisov, Sergey A., Zhukova, Nataliya A., Marenina, Mariya K., Meshkova, Yuliya V., Luzina, Olga A., Tolstikova, Tatijana G., Salakhutdinov, Nariman F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708145/
https://www.ncbi.nlm.nih.gov/pubmed/34959419
http://dx.doi.org/10.3390/pharmaceutics13122138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708145/
https://www.ncbi.nlm.nih.gov/pubmed/34959419
http://dx.doi.org/10.3390/pharmaceutics13122138

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