Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition

Human aldo-keto reductase 1B10 (AKR1B10) is overexpressed in many cancer types and is involved in chemoresistance. This makes AKR1B10 to be an interesting drug target and thus many enzyme inhibitors have been investigated. High-resolution crystallographic structures of AKR1B10 with various reversibl...

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Detalles Bibliográficos
Autores principales: Ruiz, Francesc Xavier, Parés, Xavier, Farrés, Jaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708191/
https://www.ncbi.nlm.nih.gov/pubmed/34940623
http://dx.doi.org/10.3390/metabo11120865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708191/
https://www.ncbi.nlm.nih.gov/pubmed/34940623
http://dx.doi.org/10.3390/metabo11120865

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