Heterocyclic Cathinones as Inhibitors of Kynurenine Aminotransferase II—Design, Synthesis, and Evaluation

Kynurenic acid is a neuroprotective metabolite of tryptophan formed by kynurenine aminotransferase (KAT) catalyzed transformation of kynurenine. However, its high brain levels are associated with cognitive deficit and with the pathophysiology of schizophrenia. Although several classes of KAT inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales: Maryška, Michal, Svobodová, Lucie, Dehaen, Wim, Hrabinová, Martina, Rumlová, Michaela, Soukup, Ondřej, Kuchař, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708382/
https://www.ncbi.nlm.nih.gov/pubmed/34959692
http://dx.doi.org/10.3390/ph14121291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708382/
https://www.ncbi.nlm.nih.gov/pubmed/34959692
http://dx.doi.org/10.3390/ph14121291

Ejemplares similares