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Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na(+) Channel 1.6 Enables Isoform-Selective Modulation
Voltage-gated Na(+) (Na(v)) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Na(v) channel α subunit that have been described (Na(v)1.1-Na(v)1.9), Na(v)1.1, Na(v)1.2, and Na(v)1.6 are the primary isoforms expressed in the central nervous system (...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708424/ https://www.ncbi.nlm.nih.gov/pubmed/34948337 http://dx.doi.org/10.3390/ijms222413541 |