Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na(+) Channel 1.6 Enables Isoform-Selective Modulation

Voltage-gated Na(+) (Na(v)) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Na(v) channel α subunit that have been described (Na(v)1.1-Na(v)1.9), Na(v)1.1, Na(v)1.2, and Na(v)1.6 are the primary isoforms expressed in the central nervous system (...

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Detalles Bibliográficos
Autores principales: Dvorak, Nolan M., Tapia, Cynthia M., Singh, Aditya K., Baumgartner, Timothy J., Wang, Pingyuan, Chen, Haiying, Wadsworth, Paul A., Zhou, Jia, Laezza, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708424/
https://www.ncbi.nlm.nih.gov/pubmed/34948337
http://dx.doi.org/10.3390/ijms222413541

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