Depth of the Steroid Core Location Determines the Mode of Na,K-ATPase Inhibition by Cardiotonic Steroids

Cardiotonic steroids (CTSs) are specific inhibitors of Na,K-ATPase (NKA). They induce diverse physiological effects and were investigated as potential drugs in heart diseases, hypertension, neuroinflammation, antiviral and cancer therapy. Here, we compared the inhibition mode and binding of CTSs, su...

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Detalles Bibliográficos
Autores principales: Tverskoi, Artem M., Poluektov, Yuri M., Klimanova, Elizaveta A., Mitkevich, Vladimir A., Makarov, Alexander A., Orlov, Sergei N., Petrushanko, Irina Yu., Lopina, Olga D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708600/
https://www.ncbi.nlm.nih.gov/pubmed/34948068
http://dx.doi.org/10.3390/ijms222413268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708600/
https://www.ncbi.nlm.nih.gov/pubmed/34948068
http://dx.doi.org/10.3390/ijms222413268

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