Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

Posiphen tartrate (Posiphen) is an orally available small molecule that targets a conserved regulatory element in the mRNAs of amyloid precursor protein (APP) and α-synuclein (αSYN) and inhibits their translation. APP and αSYN can cause neurodegeneration when their aggregates induce neurotoxicity. T...

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Detalles Bibliográficos
Autores principales: Chen, Xu-Qiao, Barrero, Carlos A., Vasquez-Del Carpio, Rodrigo, Reddy, E. Premkumar, Fecchio, Chiara, Merali, Salim, Deglincerti, Alessia, Fang, Cheng, Rogers, Jack, Maccecchini, Maria L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708689/
https://www.ncbi.nlm.nih.gov/pubmed/34959389
http://dx.doi.org/10.3390/pharmaceutics13122109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708689/
https://www.ncbi.nlm.nih.gov/pubmed/34959389
http://dx.doi.org/10.3390/pharmaceutics13122109

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