Utilization of Gelling Polymer to Formulate Nanoparticles Loaded with Epalrestat-Cyclodextrin Inclusion Complex: Formulation, Characterization, In-Silico Modelling and In-Vivo Toxicity Evaluation

Epalrestat (EPL) is an aldose reductase inhibitor with poor aqueous solubility that affects its therapeutic efficacy. The research study was designed to prepare epalrestat-cyclodextrins (EPL-CDs) inclusion complexes to enhance the aqueous solubility by using beta-cyclodextrin (β-CD) and sulfobutyl e...

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Detalles Bibliográficos
Autores principales: Alvi, Zunaira, Akhtar, Muhammad, Rahman, Nisar U., Hosny, Khaled M., Sindi, Amal M., Khan, Barkat A., Nazir, Imran, Sadaquat, Hadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708980/
https://www.ncbi.nlm.nih.gov/pubmed/34960901
http://dx.doi.org/10.3390/polym13244350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708980/
https://www.ncbi.nlm.nih.gov/pubmed/34960901
http://dx.doi.org/10.3390/polym13244350

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