Cargando…

Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival

Cholesterol is highly abundant within all human body cells and modulates critical cellular functions related to cellular plasticity, metabolism, and survival. The cholesterol-binding toxin pneumolysin represents an essential virulence factor of Streptococcus pneumoniae in establishing pneumonia and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kammann, Tobias, Hoff, Jessica, Yildirim, Ilknur, Shkodra, Blerina, Müller, Tina, Weber, Christine, Gräler, Markus H., Maus, Ulrich A., Paton, James C., Singer, Mervyn, Traeger, Anja, Schubert, Ulrich S., Bauer, Michael, Press, Adrian T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709088/ https://www.ncbi.nlm.nih.gov/pubmed/34940579 http://dx.doi.org/10.3390/metabo11120821

Ejemplares similares

Formulation of Liver-Specific PLGA-DY-635 Nanoparticles Loaded with the Protein Kinase C Inhibitor Bisindolylmaleimide I
por: Shkodra, Blerina, et al.
Publicado: (2020)

The Impact of Pneumolysin on the Macrophage Response to Streptococcus pneumoniae is Strain-Dependent
por: Harvey, Richard M., et al.
Publicado: (2014)

Direct Transmembrane Interaction between Actin and the Pore-Competent, Cholesterol-Dependent Cytolysin Pneumolysin
por: Hupp, Sabrina, et al.
Publicado: (2013)

Membrane Cholesterol Content and Lipid Organization Influence Melittin and Pneumolysin Pore-Forming Activity
por: Ganpule, Shamish, et al.
Publicado: (2022)

Effect of Crystallinity on the Properties of Polycaprolactone Nanoparticles Containing the Dual FLAP/mPEGS-1 Inhibitor BRP-187
por: Vollrath, Antje, et al.
Publicado: (2021)

Novel Role for the Streptococcus pneumoniae Toxin Pneumolysin in the Assembly of Biofilms
por: Shak, Joshua R., et al.
Publicado: (2013)

Pneumolysin: Pathogenesis and Therapeutic Target
por: Nishimoto, Andrew T., et al.
Publicado: (2020)

Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci
por: Dessing, Mark C, et al.
Publicado: (2008)

Inhibition of Pneumolysin Cytotoxicity by Hydrolysable Tannins
por: Maatsola, Santeri, et al.
Publicado: (2020)

Mouse, but Not Human, ApoB-100 Lipoprotein Cholesterol Is a Potent Innate Inhibitor of Streptococcus pneumoniae Pneumolysin
por: Wade, Kristin R., et al.
Publicado: (2014)

Incomplete pneumolysin oligomers form membrane pores
por: Sonnen, Andreas F.-P., et al.
Publicado: (2014)

Measuring kinetic drivers of pneumolysin pore structure
por: Gilbert, Robert J. C., et al.
Publicado: (2016)

Membrane perforation by the pore-forming toxin pneumolysin
por: Vögele, Martin, et al.
Publicado: (2019)

The Yin and Yang of Pneumolysin During Pneumococcal Infection
por: Pereira, Joana M., et al.
Publicado: (2022)

Changes in Astrocyte Shape Induced by Sublytic Concentrations of the Cholesterol-Dependent Cytolysin Pneumolysin Still Require Pore-Forming Capacity
por: Förtsch, Christina, et al.
Publicado: (2011)

The Cholesterol-Dependent Cytolysin Pneumolysin from Streptococcus pneumoniae Binds to Lipid Raft Microdomains in Human Corneal Epithelial Cells
por: Taylor, Sidney D., et al.
Publicado: (2013)

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA
por: Nerlich, Andreas, et al.
Publicado: (2018)

Ethoxy acetalated dextran nanoparticles for drug delivery: A comparative study of formulation methods
por: Behnke, Mira, et al.
Publicado: (2023)

Insights into structure and activity of natural compound inhibitors of pneumolysin
por: Li, Hongen, et al.
Publicado: (2017)

Pyruvate oxidase of Streptococcus pneumoniae contributes to pneumolysin release
por: Bryant, Joseph C., et al.
Publicado: (2016)

RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis
por: Hoff, Jessica, et al.
Publicado: (2023)

Cholesterol and its association with muscle weakness in critical illness
por: Hofmaenner, Daniel A., et al.
Publicado: (2021)

Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity
por: Shkodra-Pula, Blerina, et al.
Publicado: (2020)

β-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection
por: Li, Hongen, et al.
Publicado: (2015)

Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest
por: Rai, Prashant, et al.
Publicado: (2016)

Structural Characteristics of Pneumolysin and Its Domains in a Biomimetic Solution
por: Lee, Jongchan, et al.
Publicado: (2018)

Polyvalent Immunoglobulin Preparations Inhibit Pneumolysin-Induced Platelet Destruction
por: Wiebe, Friederike, et al.
Publicado: (2022)

Impact of Endogenous Pneumococcal Hydrogen Peroxide on the Activity and Release of Pneumolysin
por: Bazant, Jasmin, et al.
Publicado: (2023)

Persistence of Pneumolysin in the Cerebrospinal Fluid of Patients With Pneumococcal Meningitis Is Associated With Mortality
por: Wall, Emma C., et al.
Publicado: (2012)

Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression
por: Littmann, Marie, et al.
Publicado: (2009)

Passive immunization with Pneumovax(®) 23 and pneumolysin in combination with vancomycin for pneumococcal endophthalmitis
por: Sanders, Melissa E, et al.
Publicado: (2013)

Mini-Review: Novel Therapeutic Strategies to Blunt Actions of Pneumolysin in the Lungs
por: Lucas, Rudolf, et al.
Publicado: (2013)

Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen
por: Hermand, Philippe, et al.
Publicado: (2016)

Multifaceted Role of Pneumolysin in the Pathogenesis of Myocardial Injury in Community-Acquired Pneumonia
por: Anderson, Ronald, et al.
Publicado: (2018)

Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides
por: Kirkham, Lea-Ann S., et al.
Publicado: (2017)

Role of astroglial Connexin 43 in pneumolysin cytotoxicity and during pneumococcal meningitis
por: Bello, Chakir, et al.
Publicado: (2020)

Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure
por: Letsiou, Eleftheria, et al.
Publicado: (2021)

Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction
por: Batori, Robert K., et al.
Publicado: (2022)

Pneumolysin boosts the neuroinflammatory response to Streptococcus pneumoniae through enhanced endocytosis
por: Hupp, Sabrina, et al.
Publicado: (2022)

Pneumolysin suppresses the initial macrophage pro‐inflammatory response to Streptococcus pneumoniae
por: Periselneris, Jimstan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t0tc693estv04c0t1mc8ajqeje