The Promising Role of Chitosan–Poloxamer 188 Nanocrystals in Improving Diosmin Dissolution and Therapeutic Efficacy against Ferrous Sulfate-Induced Hepatic Injury in Rats

Diosmin (DSN) exhibits poor water solubility and low bioavailability. Although nanocrystals (NCs) are successful for improving drug solubility, they may undergo crystal growth. Therefore, DSN NCs were prepared, employing sonoprecipitation utilizing different stabilizers. The optimum stabilizer was c...

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Detalles Bibliográficos
Autores principales: Lotfy, Neamet S., Borg, Thanaa M., Mohamed, Elham A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709147/
https://www.ncbi.nlm.nih.gov/pubmed/34959367
http://dx.doi.org/10.3390/pharmaceutics13122087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709147/
https://www.ncbi.nlm.nih.gov/pubmed/34959367
http://dx.doi.org/10.3390/pharmaceutics13122087

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