Weakening the IF2-fMet-tRNA Interaction Suppresses the Lethal Phenotype Caused by GTPase Inactivation

Substitution of the conserved Histidine 448 present in one of the three consensus elements characterizing the guanosine nucleotide binding domain (IF2 G2) of Escherichia coli translation initiation factor IF2 resulted in impaired ribosome-dependent GTPase activity which prevented IF2 dissociation fr...

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Detalles Bibliográficos
Autores principales: Tomsic, Jerneja, Caserta, Enrico, Pon, Cynthia L., Gualerzi, Claudio O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709274/
https://www.ncbi.nlm.nih.gov/pubmed/34948034
http://dx.doi.org/10.3390/ijms222413238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709274/
https://www.ncbi.nlm.nih.gov/pubmed/34948034
http://dx.doi.org/10.3390/ijms222413238

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