Cargando…

Weakening the IF2-fMet-tRNA Interaction Suppresses the Lethal Phenotype Caused by GTPase Inactivation

Substitution of the conserved Histidine 448 present in one of the three consensus elements characterizing the guanosine nucleotide binding domain (IF2 G2) of Escherichia coli translation initiation factor IF2 resulted in impaired ribosome-dependent GTPase activity which prevented IF2 dissociation fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tomsic, Jerneja, Caserta, Enrico, Pon, Cynthia L., Gualerzi, Claudio O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709274/ https://www.ncbi.nlm.nih.gov/pubmed/34948034 http://dx.doi.org/10.3390/ijms222413238

Ejemplares similares

Disparate Phenotypes Resulting from Mutations of a Single Histidine in Switch II of Geobacillus stearothermophilus Translation Initiation Factor IF2
por: Tomsic, Jerneja, et al.
Publicado: (2020)

RNA modifications stabilize the tertiary structure of tRNA(fMet) by locally increasing conformational dynamics
por: Biedenbänder, Thomas, et al.
Publicado: (2022)

The gene fmt, encoding tRNA(fMet)-formyl transferase, is essential for normal growth of M. bovis, but not for viability
por: Vanunu, Miriam, et al.
Publicado: (2017)

Crucial contribution of the multiple copies of the initiator tRNA genes in the fidelity of tRNA(fMet) selection on the ribosomal P-site in Escherichia coli
por: Kapoor, Suman, et al.
Publicado: (2011)

Initiation of mRNA translation in bacteria: structural and dynamic aspects
por: Gualerzi, Claudio O., et al.
Publicado: (2015)

Allosteric inactivation of an engineered optogenetic GTPase
por: Jain, Abha, et al.
Publicado: (2023)

Structural mechanism of GTPase-powered ribosome-tRNA movement
por: Petrychenko, Valentyn, et al.
Publicado: (2021)

Translation initiation without IF2-dependent GTP hydrolysis
por: Fabbretti, Attilio, et al.
Publicado: (2012)

RNase MRP Cleaves Pre-tRNA(Ser-Met) in the tRNA Maturation Pathway
por: Saito, Yuichiro, et al.
Publicado: (2014)

Human Thg1 displays tRNA-inducible GTPase activity
por: Antika, Titi Rindi, et al.
Publicado: (2022)

Ribosomal selection of mRNAs with degenerate initiation triplets
por: Chengguang, He, et al.
Publicado: (2017)

Inactivation of GIRK channels weakens the pre‐ and postsynaptic inhibitory activity in dorsal raphe neurons
por: Llamosas, Nerea, et al.
Publicado: (2017)

Structure and Dynamics of tRNA(Met) Containing Core Substitutions
por: Godwin, Ryan C., et al.
Publicado: (2018)

Sustenance of Escherichia coli on a single tRNA(Met)
por: Govindan, Ashwin, et al.
Publicado: (2018)

Everolimus induces Met inactivation by disrupting the FKBP12/Met complex
por: Raimondo, Lucia, et al.
Publicado: (2016)

Weakening HIV
por: Bashyam, Hema
Publicado: (2008)

Weakened defences
por: Whyte, Chelsea
Publicado: (2020)

Correction to ‘Human Thg1 displays tRNA-inducible GTPase activity’
Publicado: (2022)

A unique conformation of the anticodon stem-loop is associated with the capacity of tRNA(f)(Met) to initiate protein synthesis
por: Barraud, Pierre, et al.
Publicado: (2008)

The antibiotic Furvina® targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias
por: Fabbretti, Attilio, et al.
Publicado: (2012)

Transcriptional and post-transcriptional events trigger de novo infB expression in cold stressed Escherichia coli
por: Brandi, Anna, et al.
Publicado: (2019)

Mutations in the anticodon stem of tRNA cause accumulation and Met22-dependent decay of pre-tRNA in yeast
por: Payea, Matthew J., et al.
Publicado: (2020)

Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight
por: Zhu, Qian, et al.
Publicado: (2022)

Weakened humoral immune responses of inactivated SARS‐CoV‐2 vaccines in patients with solid tumors
por: Chen, Zhiwei, et al.
Publicado: (2022)

Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling
por: Yuen, Hiu-Fung, et al.
Publicado: (2016)

Hypothesis: Ran GTPase-Based Potential Therapeutic Interventions Against Lethal Microbial Infections
por: Wong, Peter M.C.
Publicado: (2002)

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)
por: Kailainathan, Sumangali, et al.
Publicado: (2016)

Coping strategies weaken cells
por: LeBrasseur, Nicole
Publicado: (2006)

Intermittent Weakness and Mediastinal Weakening
por: Malik, Umer Feroze, et al.
Publicado: (2009)

Hypotheses of Cancer Weakening and Origin
por: CHAN, John Cheung Yuen
Publicado: (2015)

Frictional weakening of slip interfaces
por: Weber, B., et al.
Publicado: (2019)

On Weakening Strategies for PB Solvers
por: Le Berre, Daniel, et al.
Publicado: (2020)

Cardiomyopathy with lethal arrhythmias associated with inactivation of KLHL24
por: Hedberg-Oldfors, Carola, et al.
Publicado: (2019)

The tRNA-modifying function of MnmE is controlled by post-hydrolysis steps of its GTPase cycle
por: Prado, Silvia, et al.
Publicado: (2013)

The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases
por: Peng, Gui-Xin, et al.
Publicado: (2021)

ATM and MET kinases are synthetic lethal with non-genotoxic activation of p53
por: Sullivan, Kelly D., et al.
Publicado: (2012)

Ribosome inactivation by Escherichia coli GTPase RsgA inhibits T4 phage
por: Fernández-García, Laura, et al.
Publicado: (2023)

Unconventional decoding of the AUA codon as methionine by mitochondrial tRNA(Met) with the anticodon f(5)CAU as revealed with a mitochondrial in vitro translation system
por: Takemoto, Chie, et al.
Publicado: (2009)

Inactivating Mutations of the IK Gene Weaken Ku80/Ku70-Mediated DNA Repair and Sensitize Endometrial Cancer to Chemotherapy
por: Gao, Chao, et al.
Publicado: (2021)

HIF Stabilization Weakens Primary Cilia
por: Resnick, Andrew
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sl5nq2g541976kmrra4bmgpunr