Characterization of the PLN p.Arg14del Mutation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Phospholamban (PLN) is the natural inhibitor of the sarco/endoplasmic reticulum Ca(2+) ATP-ase (SERCA2a). Heterozygous PLN p.Arg14del mutation is associated with an arrhythmogenic dilated cardiomyopathy (DCM), whose pathogenesis has been attributed to SERCA2a “superinhibition”. Aim: To test in cardi...

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Detalles Bibliográficos
Autores principales: Badone, Beatrice, Ronchi, Carlotta, Lodola, Francesco, Knaust, Anika E., Hansen, Arne, Eschenhagen, Thomas, Zaza, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709382/
https://www.ncbi.nlm.nih.gov/pubmed/34948294
http://dx.doi.org/10.3390/ijms222413500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709382/
https://www.ncbi.nlm.nih.gov/pubmed/34948294
http://dx.doi.org/10.3390/ijms222413500

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