Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin

Huntington Disease (HD) is a dominant, lethal neurodegenerative disorder caused by the abnormal expansion (>35 copies) of a CAG triplet located in exon 1 of the HTT gene encoding the huntingtin protein (Htt). Mutated Htt (mHtt) easily aggregates, thereby inducing ER stress that in turn leads to n...

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Detalles Bibliográficos
Autores principales: Fiorillo, Annarita, Morea, Veronica, Colotti, Gianni, Ilari, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709430/
https://www.ncbi.nlm.nih.gov/pubmed/34945781
http://dx.doi.org/10.3390/jpm11121309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709430/
https://www.ncbi.nlm.nih.gov/pubmed/34945781
http://dx.doi.org/10.3390/jpm11121309

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