Assessment of Normal Tissue Radiosensitivity by Evaluating DNA Damage and Repair Kinetics in Human Brain Organoids

DNA-double strand break (DSB), detected by immunostaining of key proteins orchestrating repair, like γH2AX and 53BP1, is well established as a surrogate for tissue radiosensitivity. We hypothesized that the generation of normal brain 3D organoids (“mini-brains”) from human induced pluripotent stem c...

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Detalles Bibliográficos
Autores principales: Bojcevski, Jovana, Wang, Changwen, Liu, Haikun, Abdollahi, Amir, Dokic, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709464/
https://www.ncbi.nlm.nih.gov/pubmed/34947991
http://dx.doi.org/10.3390/ijms222413195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709464/
https://www.ncbi.nlm.nih.gov/pubmed/34947991
http://dx.doi.org/10.3390/ijms222413195

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