Cargando…

Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study

BACKGROUND: Lipid metabolism plays an important role in viral infections. We aimed to assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and NPC1L1 inhibitior) on COVID-19 outcomes using two-sample Mendelian randomization (MR) study. METHODS: We used two kinds of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Wuqing, Xiao, Jun, Ji, Jianguang, Chen, Liangwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Epidemiology and Global Health
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709572/ https://www.ncbi.nlm.nih.gov/pubmed/34866576 http://dx.doi.org/10.7554/eLife.73873

Ejemplares similares

Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis
por: Yuan, Shuai, et al.
Publicado: (2023)

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health
por: Davies, Neil Martin, et al.
Publicado: (2019)

Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity
por: Carrasquilla, Germán D, et al.
Publicado: (2022)

Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study
por: Richardson, Tom G, et al.
Publicado: (2023)

Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study
por: Howe, Laurence J, et al.
Publicado: (2022)

Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study
por: Richardson, Tom G, et al.
Publicado: (2022)

Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor
por: Liu, Hui, et al.
Publicado: (2021)

Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
por: Sundquist, Jan, et al.
Publicado: (2014)

Body mass index and childhood symptoms of depression, anxiety, and attention-deficit hyperactivity disorder: A within-family Mendelian randomization study
por: Hughes, Amanda M, et al.
Publicado: (2022)

Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation
por: Schooling, CM, et al.
Publicado: (2020)

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
por: Martin, Susan, et al.
Publicado: (2022)

Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries
por: Li, Xinxuan, et al.
Publicado: (2022)

Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation
por: Martin, Susan, et al.
Publicado: (2022)

Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome
por: Cortez Cardoso Penha, Ricardo, et al.
Publicado: (2023)

Association between bisphosphonate use and COVID-19 related outcomes
por: Thompson, Jeffrey, et al.
Publicado: (2023)

Clinical characteristics, racial inequities, and outcomes in patients with breast cancer and COVID-19: A COVID-19 and cancer consortium (CCC19) cohort study
por: Nagaraj, Gayathri, et al.
Publicado: (2023)

Identification of drugs associated with reduced severity of COVID-19 – a case-control study in a large population
por: Israel, Ariel, et al.
Publicado: (2021)

Effects of side-effect risk framing strategies on COVID-19 vaccine intentions: a randomized controlled trial
por: Sudharsanan, Nikkil, et al.
Publicado: (2022)

Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden
por: Huang, Wuqing, et al.
Publicado: (2020)

A systematic review of population-based studies on lipid profiles in Latin America and the Caribbean
por: Carrillo-Larco, Rodrigo M, et al.
Publicado: (2020)

Ontogeny of circulating lipid metabolism in pregnancy and early childhood – a longitudinal population study
por: Burugupalli, Satvika, et al.
Publicado: (2022)

Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection
por: Koenecke, Allison, et al.
Publicado: (2021)

The impact of lag time to cancer diagnosis and treatment on clinical outcomes prior to the COVID-19 pandemic: A scoping review of systematic reviews and meta-analyses
por: Tope, Parker, et al.
Publicado: (2023)

Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19
por: Granados, Alejandro A, et al.
Publicado: (2023)

Early analysis of the Australian COVID-19 epidemic
por: Price, David J, et al.
Publicado: (2020)

Antimicrobial resistance and COVID-19: Intersections and implications
por: Knight, Gwenan M, et al.
Publicado: (2021)

Fitness gains hamper efforts to tackle drug resistance
por: Dutta, Shanta
Publicado: (2013)

Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study
por: Klén, Riku, et al.
Publicado: (2023)

Evidence for transmission of COVID-19 prior to symptom onset
por: Tindale, Lauren C, et al.
Publicado: (2020)

SARS-CoV-2 (COVID-19) by the numbers
por: Bar-On, Yinon M, et al.
Publicado: (2020)

Quantifying the impact of quarantine duration on COVID-19 transmission
por: Ashcroft, Peter, et al.
Publicado: (2021)

The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials
por: Liu, Yupeng, et al.
Publicado: (2022)

Genomic epidemiology of COVID-19 in care homes in the east of England
por: Hamilton, William L, et al.
Publicado: (2021)

A comprehensive look at the COVID-19 pandemic death toll
por: Simonsen, Lone, et al.
Publicado: (2021)

COVID-19 as a catalyst for reimagining cervical cancer prevention
por: Luckett, Rebecca, et al.
Publicado: (2023)

Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19
por: Gostic, Katelyn, et al.
Publicado: (2020)

Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality
por: Casadevall, Arturo, et al.
Publicado: (2021)

Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics
por: Ma, Kevin C, et al.
Publicado: (2021)

A modelled analysis of the impact of COVID-19-related disruptions to HPV vaccination
por: Velentzis, Louiza S, et al.
Publicado: (2023)

The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum
por: Masserey, Thiery, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kgki8g9cpa8qs195jh5cqirr3t