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Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods
The transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neur...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709574/ https://www.ncbi.nlm.nih.gov/pubmed/34859784 http://dx.doi.org/10.7554/eLife.70685 |
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author | Loureiro-Campos, Eduardo Mateus-Pinheiro, António Patrício, Patrícia Soares-Cunha, Carina Silva, Joana Sardinha, Vanessa Morais Mendes-Pinheiro, Bárbara Silveira-Rosa, Tiago Domingues, Ana Verónica Rodrigues, Ana João Oliveira, João Sousa, Nuno Alves, Nuno Dinis Pinto, Luísa |
author_facet | Loureiro-Campos, Eduardo Mateus-Pinheiro, António Patrício, Patrícia Soares-Cunha, Carina Silva, Joana Sardinha, Vanessa Morais Mendes-Pinheiro, Bárbara Silveira-Rosa, Tiago Domingues, Ana Verónica Rodrigues, Ana João Oliveira, João Sousa, Nuno Alves, Nuno Dinis Pinto, Luísa |
author_sort | Loureiro-Campos, Eduardo |
collection | PubMed |
description | The transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neurogenic, behavioral, and functional impact of a constitutive and heterozygous AP2γ deletion in mice from early postnatal development until adulthood. AP2γ deficiency promotes downregulation of hippocampal glutamatergic neurogenesis, altering the ontogeny of emotional and memory behaviors associated with hippocampus formation. The impairments induced by AP2γ constitutive deletion since early development leads to an anxious-like phenotype and memory impairments as early as the juvenile phase. These behavioral impairments either persist from the juvenile phase to adulthood or emerge in adult mice with deficits in behavioral flexibility and object location recognition. Collectively, we observed a progressive and cumulative impact of constitutive AP2γ deficiency on the hippocampal glutamatergic neurogenic process, as well as alterations on limbic-cortical connectivity, together with functional behavioral impairments. The results herein presented demonstrate the modulatory role exerted by the AP2γ transcription factor and the relevance of hippocampal neurogenesis in the development of emotional states and memory processes. |
format | Online Article Text |
id | pubmed-8709574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-87095742022-01-04 Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods Loureiro-Campos, Eduardo Mateus-Pinheiro, António Patrício, Patrícia Soares-Cunha, Carina Silva, Joana Sardinha, Vanessa Morais Mendes-Pinheiro, Bárbara Silveira-Rosa, Tiago Domingues, Ana Verónica Rodrigues, Ana João Oliveira, João Sousa, Nuno Alves, Nuno Dinis Pinto, Luísa eLife Developmental Biology The transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neurogenic, behavioral, and functional impact of a constitutive and heterozygous AP2γ deletion in mice from early postnatal development until adulthood. AP2γ deficiency promotes downregulation of hippocampal glutamatergic neurogenesis, altering the ontogeny of emotional and memory behaviors associated with hippocampus formation. The impairments induced by AP2γ constitutive deletion since early development leads to an anxious-like phenotype and memory impairments as early as the juvenile phase. These behavioral impairments either persist from the juvenile phase to adulthood or emerge in adult mice with deficits in behavioral flexibility and object location recognition. Collectively, we observed a progressive and cumulative impact of constitutive AP2γ deficiency on the hippocampal glutamatergic neurogenic process, as well as alterations on limbic-cortical connectivity, together with functional behavioral impairments. The results herein presented demonstrate the modulatory role exerted by the AP2γ transcription factor and the relevance of hippocampal neurogenesis in the development of emotional states and memory processes. eLife Sciences Publications, Ltd 2021-12-03 /pmc/articles/PMC8709574/ /pubmed/34859784 http://dx.doi.org/10.7554/eLife.70685 Text en © 2021, Loureiro-Campos et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Loureiro-Campos, Eduardo Mateus-Pinheiro, António Patrício, Patrícia Soares-Cunha, Carina Silva, Joana Sardinha, Vanessa Morais Mendes-Pinheiro, Bárbara Silveira-Rosa, Tiago Domingues, Ana Verónica Rodrigues, Ana João Oliveira, João Sousa, Nuno Alves, Nuno Dinis Pinto, Luísa Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods |
title | Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods |
title_full | Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods |
title_fullStr | Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods |
title_full_unstemmed | Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods |
title_short | Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods |
title_sort | constitutive deficiency of the neurogenic hippocampal modulator ap2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709574/ https://www.ncbi.nlm.nih.gov/pubmed/34859784 http://dx.doi.org/10.7554/eLife.70685 |
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