SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

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The pathogenesis of COVID-19 is associated with a hyperinflammatory response; however, the precise mechanism of SARS-CoV-2-induced inflammation is poorly understood. Here, we investigated direct inflammatory functions of major structural proteins of SARS-CoV-2. We observed that spike (S) protein pot...

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Detalles Bibliográficos
Autores principales: Khan, Shahanshah, Shafiei, Mahnoush S, Longoria, Christopher, Schoggins, John W, Savani, Rashmin C, Zaki, Hasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709575/
https://www.ncbi.nlm.nih.gov/pubmed/34866574
http://dx.doi.org/10.7554/eLife.68563
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