Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants

The exquisite specificity of Toll-like receptors (TLRs) to sense microbial molecular signatures is used as a powerful tool to pinpoint microbial contaminants. Various cellular systems, from native human blood cells to transfected cell lines exploit TLRs as pyrogen detectors in biological preparation...

Descripción completa

Detalles Bibliográficos
Autores principales: Seumen, Clovis H. T., Tomasiunaite, Urte, Legler, Daniel F., Hauck, Christof R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709846/
https://www.ncbi.nlm.nih.gov/pubmed/34952917
http://dx.doi.org/10.1038/s41598-021-03618-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709846/
https://www.ncbi.nlm.nih.gov/pubmed/34952917
http://dx.doi.org/10.1038/s41598-021-03618-9

Ejemplares similares