Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brainstem tumor for which radiation is the only treatment. Case studies report a clinical response to ONC201 for patients with H3K27M-mutant gliomas. Oncoceutics (ONC201) is only available in the United States and Japan; howeve...

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Detalles Bibliográficos
Autores principales: Duchatel, Ryan J, Mannan, Abdul, Woldu, Ameha S, Hawtrey, Tom, Hindley, Phoebe A, Douglas, Alicia M, Jackson, Evangeline R, Findlay, Izac J, Germon, Zacary P, Staudt, Dilana, Kearney, Padraic S, Smith, Nathan D, Hindley, Kate E, Cain, Jason E, André, Nicolas, La Madrid, Andres Morales, Nixon, Brett, De Iuliis, Geoffry N, Nazarian, Javad, Irish, Kathleen, Alvaro, Frank, Eisenstat, David D, Beck, Alexander, Vitanza, Nicholas A, Mueller, Sabine, Morris, Jonathan C, Dun, Matthew D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709907/
https://www.ncbi.nlm.nih.gov/pubmed/34988452
http://dx.doi.org/10.1093/noajnl/vdab169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709907/
https://www.ncbi.nlm.nih.gov/pubmed/34988452
http://dx.doi.org/10.1093/noajnl/vdab169

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