IDH-wild type glioblastomas featuring at least 30% giant cells are characterized by frequent RB1 and NF1 alterations and hypermutation

Giant cell glioblastoma (GC-GBM) is a rare variant of IDH-wt GBM histologically characterized by the presence of numerous multinucleated giant cells and molecularly considered a hybrid between IDH-wt and IDH-mutant GBM. The lack of an objective definition, specifying the percentage of giant cells re...

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Detalles Bibliográficos
Autores principales: Barresi, Valeria, Simbolo, Michele, Mafficini, Andrea, Martini, Maurizio, Calicchia, Martina, Piredda, Maria Liliana, Ciaparrone, Chiara, Bonizzato, Giada, Ammendola, Serena, Caffo, Maria, Pinna, Giampietro, Sala, Francesco, Lawlor, Rita Teresa, Ghimenton, Claudio, Scarpa, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709962/
https://www.ncbi.nlm.nih.gov/pubmed/34952640
http://dx.doi.org/10.1186/s40478-021-01304-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709962/
https://www.ncbi.nlm.nih.gov/pubmed/34952640
http://dx.doi.org/10.1186/s40478-021-01304-5

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