Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor

PURPOSE: Molecular tumor profiling is becoming a routine part of clinical cancer care, typically involving tumor-only panel testing without matched germline. We hypothesized that integrated germline sequencing could improve clinical interpretation and enhance the identification of germline variants...

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Detalles Bibliográficos
Autores principales: Schienda, Jaclyn, Church, Alanna J., Corson, Laura B., Decker, Brennan, Clinton, Catherine M., Manning, Danielle K., Imamovic-Tuco, Alma, Reidy, Deirdre, Strand, Gianna R., Applebaum, Mark A., Bagatell, Rochelle, DuBois, Steven G., Glade-Bender, Julia L., Kang, Wenjun, Kim, AeRang, Laetsch, Theodore W., Macy, Margaret E., Maese, Luke, Pinto, Navin, Sabnis, Amit J., Schiffman, Joshua D., Colace, Susan I., Volchenboum, Samuel L., Weiser, Daniel A., Nowak, Jonathan A., Lindeman, Neal I., Janeway, Katherine A., Crompton, Brian D., Kamihara, Junne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2021
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710335/
https://www.ncbi.nlm.nih.gov/pubmed/34964003
http://dx.doi.org/10.1200/PO.21.00281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710335/
https://www.ncbi.nlm.nih.gov/pubmed/34964003
http://dx.doi.org/10.1200/PO.21.00281

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