Unraveling the Influence of K280 Acetylation on the Conformational Features of Tau Core Fragment: A Molecular Dynamics Simulation Study

Abnormal aggregation of the microtubule-associated protein Tau is closely associated with tauopathies, including Alzheimer’s disease and chronic traumatic encephalopathy. The hexapeptide 275VQIINK280 (PHF6*), a fibril-nucleating core motif of Tau, has been shown to play a vital role in the aggregati...

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Detalles Bibliográficos
Autores principales: Zou, Yu, Guan, Lulu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710698/
https://www.ncbi.nlm.nih.gov/pubmed/34966788
http://dx.doi.org/10.3389/fmolb.2021.801577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710698/
https://www.ncbi.nlm.nih.gov/pubmed/34966788
http://dx.doi.org/10.3389/fmolb.2021.801577

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