Cargando…

Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination – A Preclinical Study in Model Mice

Amyloidogenic protein oligomers are thought to play an important role in the pathogenesis of neurodegenerative dementia, including Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies. Previously we demonstrated that oral or intranasal rifampicin improved the cognition of APP-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Umeda, Tomohiro, Sakai, Ayumi, Shigemori, Keiko, Yokota, Ayumi, Kumagai, Toru, Tomiyama, Takami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710719/ https://www.ncbi.nlm.nih.gov/pubmed/34966254 http://dx.doi.org/10.3389/fnins.2021.763476

Ejemplares similares

Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers
por: Umeda, Tomohiro, et al.
Publicado: (2021)

Intranasal rifampicin for Alzheimer's disease prevention
por: Umeda, Tomohiro, et al.
Publicado: (2018)

Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice
por: Umeda, Tomohiro, et al.
Publicado: (2022)

C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice
por: Hatanaka, Yukari, et al.
Publicado: (2022)

Peripheral Aβ acts as a negative modulator of insulin secretion
por: Shigemori, Keiko, et al.
Publicado: (2022)

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
por: Umeda, Tomohiro, et al.
Publicado: (2015)

Resveratrol Oligomers for the Prevention and Treatment of Cancers
por: Xue, You-Qiu, et al.
Publicado: (2014)

Resveratrol oligomer structure in Dipterocarpaceaeous plants
por: Ito, Tetsuro
Publicado: (2020)

Regioselective Reactions for Programmable Resveratrol Oligomer Synthesis
por: Snyder, Scott A., et al.
Publicado: (2011)

Correction to: Resveratrol oligomer structure in Dipterocarpaceaeous plants
por: Ito, Tetsuro
Publicado: (2020)

Update on Phytochemistry and Pharmacology of Naturally Occurring Resveratrol Oligomers
por: Shen, Jie, et al.
Publicado: (2017)

Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease
por: Kosyakovsky, Jacob, et al.
Publicado: (2021)

Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain
por: Amano, Akiko, et al.
Publicado: (2023)

Total Synthesis of the Resveratrol Oligomers (±)‐Ampelopsin B and (±)‐ϵ‐Viniferin
por: Lindgren, Anders E. G., et al.
Publicado: (2015)

New Resveratrol Oligomer Derivatives from the Roots of Rheum lhasaense
por: Liu, Wen-Bo, et al.
Publicado: (2013)

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice
por: Umeda, Tomohiro, et al.
Publicado: (2017)

Erratum: Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
por: Umeda, T, et al.
Publicado: (2016)

Resveratrol: A Focus on Several Neurodegenerative Diseases
por: Tellone, Ester, et al.
Publicado: (2015)

Preclinical progression of neurodegenerative diseases
por: Katsuno, Masahisa, et al.
Publicado: (2018)

Intranasal Delivery of Nerve Growth Factor in Neurodegenerative Diseases and Neurotrauma
por: Manni, Luigi, et al.
Publicado: (2021)

Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice
por: Umeda, Tomohiro, et al.
Publicado: (2015)

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
por: Thibaudeau, Tiffany A., et al.
Publicado: (2018)

Acuminatol and Other Antioxidative Resveratrol Oligomers from the Stem Bark of Shorea acuminata
por: Muhammad, Norhayati, et al.
Publicado: (2012)

Apraxias in Neurodegenerative Dementias
por: Chandra, Sadanandavalli Retnaswami, et al.
Publicado: (2015)

Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease
por: Yanagisawa, Daijiro, et al.
Publicado: (2021)

A review of formulations and preclinical studies of inhaled rifampicin for its clinical translation
por: Khadka, Prakash, et al.
Publicado: (2022)

Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice
por: Monteillier, Aymeric, et al.
Publicado: (2018)

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases
por: Nilson, Ashley N., et al.
Publicado: (2016)

Neurofilament light oligomers in neurodegenerative diseases: quantification by homogeneous immunoassay in cerebrospinal fluid
por: Meda, Francisco J., et al.
Publicado: (2023)

How does resveratrol influence the genesis of some neurodegenerative diseases?
por: Tellone, Ester, et al.
Publicado: (2016)

Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models
por: Ohshima, Yoichi, et al.
Publicado: (2018)

Recent progress in the intranasal PLGA-based drug delivery for neurodegenerative diseases treatment
por: Aghaei Delche, Nasim, et al.
Publicado: (2023)

Disease Modifying Therapies for Alzheimer's Disease Targeting Aβ Oligomers: Implications for Therapeutic Mechanisms
por: Matsubara, Etsuro, et al.
Publicado: (2013)

Resveratrol Oligomers, Plant-Produced Natural Products With Anti-virulence and Plant Immune-Priming Roles
por: Kang, Ji Eun, et al.
Publicado: (2022)

Resveratrol: Multi-Targets Mechanism on Neurodegenerative Diseases Based on Network Pharmacology
por: Wang, Wenjun, et al.
Publicado: (2020)

The basics of preclinical drug development for neurodegenerative disease indications
por: Steinmetz, Karen L, et al.
Publicado: (2009)

Preclinical Research of Dihydromyricetin for Brain Aging and Neurodegenerative Diseases
por: Martínez-Coria, Hilda, et al.
Publicado: (2019)

Forecasting Clinical Dose–Response From Preclinical Studies in Tuberculosis Research: Translational Predictions With Rifampicin
por: Wicha, Sebastian G., et al.
Publicado: (2018)

Progress in the Preclinical and Clinical Study of Resveratrol for Vascular Metabolic Disease
por: Fan, Dongxiao, et al.
Publicado: (2022)

White matter hyperintensities and neurodegenerative dementias
por: Sassi, Celeste
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jfe2o2f1v52afu7eatll3ammf9