Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade

OBJECTIVE: Our goals were to evaluate the antitumour efficacy of Lactobacillus rhamnosus GG (LGG) in combination with immune checkpoint blockade (ICB) immunotherapies on tumour growth and to investigate the underlying mechanisms. DESIGN: We used murine models of colorectal cancer and melanoma to eva...

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Detalles Bibliográficos
Autores principales: Si, Wei, Liang, Hua, Bugno, Jason, Xu, Qi, Ding, Xingchen, Yang, Kaiting, Fu, Yanbin, Weichselbaum, Ralph R, Zhao, Xin, Wang, Liangliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Gut Microbiota
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710942/
https://www.ncbi.nlm.nih.gov/pubmed/33685966
http://dx.doi.org/10.1136/gutjnl-2020-323426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710942/
https://www.ncbi.nlm.nih.gov/pubmed/33685966
http://dx.doi.org/10.1136/gutjnl-2020-323426

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