Phase 1 Dose-Escalation Study of Plasma Kallikrein Inhibitor THR-149 for the Treatment of Diabetic Macular Edema

PURPOSE: The purpose of this study was to evaluate the safety and preliminary efficacy of a single intravitreal injection of 3 dose levels of THR-149 in adults with center-involved diabetic macular edema (DME). METHODS: A phase 1, open-label, multicenter 3 + 3 dose-esclation study with 3-month follo...

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Detalles Bibliográficos
Autores principales: Dugel, Pravin U., Khanani, Arshad M., Berger, Brian B., Patel, Sunil, Fineman, Mitchell, Jaffe, Glenn J., Kozma-Wiebe, Petra, Heier, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711005/
https://www.ncbi.nlm.nih.gov/pubmed/34940810
http://dx.doi.org/10.1167/tvst.10.14.28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711005/
https://www.ncbi.nlm.nih.gov/pubmed/34940810
http://dx.doi.org/10.1167/tvst.10.14.28

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