Bhlhe40: Gatekeeper of the GC

The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211406) report that Bhlhe40 restrains GC output through distinct regulatory roles in both a...

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Detalles Bibliográficos
Autores principales: Nutt, Stephen L., Tellier, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711044/
https://www.ncbi.nlm.nih.gov/pubmed/34940789
http://dx.doi.org/10.1084/jem.20212333
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author Nutt, Stephen L.
Tellier, Julie
author_facet Nutt, Stephen L.
Tellier, Julie
author_sort Nutt, Stephen L.
collection PubMed
description The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211406) report that Bhlhe40 restrains GC output through distinct regulatory roles in both arms of the response.
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spelling pubmed-87110442022-07-14 Bhlhe40: Gatekeeper of the GC Nutt, Stephen L. Tellier, Julie J Exp Med Insights The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211406) report that Bhlhe40 restrains GC output through distinct regulatory roles in both arms of the response. Rockefeller University Press 2021-12-23 /pmc/articles/PMC8711044/ /pubmed/34940789 http://dx.doi.org/10.1084/jem.20212333 Text en © 2021 Nutt and Tellier https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Nutt, Stephen L.
Tellier, Julie
Bhlhe40: Gatekeeper of the GC
title Bhlhe40: Gatekeeper of the GC
title_full Bhlhe40: Gatekeeper of the GC
title_fullStr Bhlhe40: Gatekeeper of the GC
title_full_unstemmed Bhlhe40: Gatekeeper of the GC
title_short Bhlhe40: Gatekeeper of the GC
title_sort bhlhe40: gatekeeper of the gc
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711044/
https://www.ncbi.nlm.nih.gov/pubmed/34940789
http://dx.doi.org/10.1084/jem.20212333
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