Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation

Regulatory T (T(reg)) cells play crucial roles in suppressing deleterious immune response. Here, we investigate how T(reg) cells are mechanistically induced in vitro (iT(reg)) and stabilized via transcriptional regulation of T(reg) lineage-specifying factor Foxp3. We find that acetylation of histone...

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Detalles Bibliográficos
Autores principales: Li, Jun, Xu, Beisi, He, Minghong, Zong, Xinying, Cunningham, Trevor, Sha, Cher, Fan, Yiping, Cross, Richard, Hanna, Jacob H., Feng, Yongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711072/
https://www.ncbi.nlm.nih.gov/pubmed/34910919
http://dx.doi.org/10.1016/j.celrep.2021.110124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711072/
https://www.ncbi.nlm.nih.gov/pubmed/34910919
http://dx.doi.org/10.1016/j.celrep.2021.110124

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