Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome

Amyloid beta (Aβ) is thought to play a critical role in the pathogenesis of Alzheimer’s disease (AD). Prion-like Aβ polymorphs, or “strains”, can have varying pathogenicity and may underlie the phenotypic heterogeneity of the disease. In order to develop effective AD therapies, it is critical to ide...

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Detalles Bibliográficos
Autores principales: Maxwell, Alison M., Yuan, Peng, Rivera, Brianna M., Schaaf, Wilder, Mladinov, Mihovil, Prasher, Vee P., Robinson, Andrew C., DeGrado, William F., Condello, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711167/
https://www.ncbi.nlm.nih.gov/pubmed/34961556
http://dx.doi.org/10.1186/s40478-021-01298-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711167/
https://www.ncbi.nlm.nih.gov/pubmed/34961556
http://dx.doi.org/10.1186/s40478-021-01298-0

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