A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD(2)-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus

BACKGROUND: Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory mediators. We previously reported that a surge in prostaglandin D(2) (PGD(2)) production and PGD(2)-induced microglial activat...

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Detalles Bibliográficos
Autores principales: Iwasa, Kensuke, Yamamoto, Shinji, Yamashina, Kota, Yagishita-kyo, Nan, Maruyama, Kei, Awaji, Takeo, Takei, Yoshinori, Hirasawa, Akira, Yoshikawa, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711188/
https://www.ncbi.nlm.nih.gov/pubmed/34961526
http://dx.doi.org/10.1186/s12974-021-02361-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711188/
https://www.ncbi.nlm.nih.gov/pubmed/34961526
http://dx.doi.org/10.1186/s12974-021-02361-2

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