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A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD(2)-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus
BACKGROUND: Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory mediators. We previously reported that a surge in prostaglandin D(2) (PGD(2)) production and PGD(2)-induced microglial activat...
Autores principales: | Iwasa, Kensuke, Yamamoto, Shinji, Yamashina, Kota, Yagishita-kyo, Nan, Maruyama, Kei, Awaji, Takeo, Takei, Yoshinori, Hirasawa, Akira, Yoshikawa, Keisuke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711188/ https://www.ncbi.nlm.nih.gov/pubmed/34961526 http://dx.doi.org/10.1186/s12974-021-02361-2 |
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