The Nature of Diamino Linker and Halogen Bonding Define Selectivity of Pyrrolopyrimidine-Based LIMK1 Inhibitors

The LIM-domain kinase (LIMK) family consists of two isoforms, LIMK1 and LIMK2, which are highly homologous, making selective inhibitor development challenging. LIMK regulates dynamics of the actin cytoskeleton, thereby impacting many cellular functions including cell morphology and motility. Here, w...

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Detalles Bibliográficos
Autores principales: Ariawan, Daryl, Au, Carol, Paric, Esmeralda, Fath, Thomas, Ke, Yazi D., Kassiou, Michael, van Eersel, Janet, Ittner, Lars M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711653/
https://www.ncbi.nlm.nih.gov/pubmed/34966720
http://dx.doi.org/10.3389/fchem.2021.781213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711653/
https://www.ncbi.nlm.nih.gov/pubmed/34966720
http://dx.doi.org/10.3389/fchem.2021.781213

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