Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4

Inhibition of phosphodiesterase 2 and 4 (PDE2A and PDE4) increases the intracellular cAMP and/or cGMP levels, which may prevent Amyloid β 42 oligomers (Aβ) related cognitive impairment and dementias. Baicalein, one of natural flavones found in the root of Scutellaria baicalensis Georgi, has a wide r...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Jing, Li, Yuanyuan, Zhang, Yi, Chen, Jie, Gao, Jianqing, Zhang, Tianyuan, Shang, Xiaoguang, Zhang, Xiangnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711762/
https://www.ncbi.nlm.nih.gov/pubmed/34966284
http://dx.doi.org/10.3389/fphar.2021.794458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711762/
https://www.ncbi.nlm.nih.gov/pubmed/34966284
http://dx.doi.org/10.3389/fphar.2021.794458

Ejemplares similares