Cargando…

Have (R)-[(11)C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies

PURPOSE: The prototypical TSPO radiotracer (R)-[(11)C]PK11195 has been used in humans for more than thirty years to visualize neuroinflammation in several pathologies. Alternative radiotracers have been developed to improve signal-to-noise ratio and started to be tested clinically in 2008. Here we e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chauveau, Fabien, Becker, Guillaume, Boutin, Hervé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712292/ https://www.ncbi.nlm.nih.gov/pubmed/34387719 http://dx.doi.org/10.1007/s00259-021-05425-w

Ejemplares similares

Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
por: Kumar, Ajay, et al.
Publicado: (2012)

Kinetic analysis and test-retest variability of the radioligand [(11)C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
por: Jučaite, Aurelija, et al.
Publicado: (2012)

Abnormal neuroinflammation in fibromyalgia and CRPS using [(11)C]-(R)-PK11195 PET
por: Seo, Seongho, et al.
Publicado: (2021)

No Signs of Neuroinflammation in Women With Chronic Fatigue Syndrome or Q Fever Fatigue Syndrome Using the TSPO Ligand [(11)C]-PK11195
por: Raijmakers, Ruud, et al.
Publicado: (2021)

The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy
por: Lan, Nannan, et al.
Publicado: (2021)

(11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
por: Nicastro, Nicolas, et al.
Publicado: (2019)

[(11)C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease
por: van den Ameele, Jelle, et al.
Publicado: (2021)

[(11)C]-DPA-713 and [(18)F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [(11)C]-(R)-PK11195 in a Rat Model of Herpes Encephalitis
por: Doorduin, Janine, et al.
Publicado: (2009)

Textural properties of microglial activation in Alzheimer’s disease as measured by (R)-[(11)C]PK11195 PET
por: Lapo Pais, Marta, et al.
Publicado: (2023)

TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells
por: Feng, Hao, et al.
Publicado: (2020)

In Vivo Cerebral Translocator Protein (TSPO) Binding and Its Relationship with Blood Adiponectin Levels in Treatment-Naïve Young Adults with Major Depression: A [(11)C]PK11195 PET Study
por: Joo, Yo-Han, et al.
Publicado: (2021)

[(18)F]DPA-714: Direct Comparison with [(11)C]PK11195 in a Model of Cerebral Ischemia in Rats
por: Boutin, Hervé, et al.
Publicado: (2013)

[(11)C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy
por: Passamonti, Luca, et al.
Publicado: (2018)

The Effect of the Classical TSPO Ligand PK 11195 on In Vitro Cobalt Chloride Model of Hypoxia-like Condition in Lung and Brain Cell Lines
por: Amara, Rula, et al.
Publicado: (2022)

A Modest Increase in (11)C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index
por: Schubert, Julia J., et al.
Publicado: (2021)

(11)C‐PK11195 PET–based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis
por: Tondo, Giacomo, et al.
Publicado: (2020)

In vivo (R)-[(11)C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis
por: van der Doef, Thalia F, et al.
Publicado: (2016)

Potential of [(11)C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model
por: de Souza, Aline Morais, et al.
Publicado: (2022)

The TSPO Ligands 2-Cl-MGV-1, MGV-1, and PK11195 Differentially Suppress the Inflammatory Response of BV-2 Microglial Cell to LPS
por: Azrad, Maya, et al.
Publicado: (2019)

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195
por: Guedes, Carlos Eduardo Sampaio, et al.
Publicado: (2018)

Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies
por: Yaqub, Maqsood, et al.
Publicado: (2012)

Evaluation of (R)-[(11)C]PK11195 PET/MRI for Spinal Cord-Related Neuropathic Pain in Patients with Cervical Spinal Disorders
por: Kitade, Makoto, et al.
Publicado: (2022)

Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [(11)C]-(R)-PK11195 PET and MRI
por: Yankam Njiwa, J, et al.
Publicado: (2016)

Noninvasive PK11195‐PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease
por: Kang, Yeona, et al.
Publicado: (2018)

The Efficacy of the Novel TSPO Ligands 2-Cl-MGV-1 and 2,4-Di-Cl-MGV-1 Compared to the Classical TSPO Ligand PK 11195 to Counteract the Release of Chemokines from LPS-Stimulated BV-2 Microglial Cells
por: Monga, Sheelu, et al.
Publicado: (2020)

[(11)C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches
por: Su, Zhangjie, et al.
Publicado: (2013)

Comparison of four (11)C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios
por: Fujita, Masahiro, et al.
Publicado: (2017)

Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.
por: da Silva, Marcelo Barreto Spillere, et al.
Publicado: (2004)

[(11)C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study
por: Jeon, So Yeon, et al.
Publicado: (2017)

Test-retest reliability and convergent validity of (R)-[(11)C]PK11195 outcome measures without arterial input function
por: Plavén-Sigray, Pontus, et al.
Publicado: (2018)

The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
por: Ye, Chen, et al.
Publicado: (2020)

Analysis of PK11195 concentrations in rodent whole blood and tissue samples by rapid and reproducible chromatographic method to support target-occupancy PET studies
por: Stadulytė, Agnė, et al.
Publicado: (2019)

In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer’s Brain Tissue
por: Ni, Ruiqing, et al.
Publicado: (2021)

PT637. [11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: a pilot study
por: Jeon, Soyeon
Publicado: (2016)

(11)C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: a cross-sectional study
por: de Souza, Aline Morais, et al.
Publicado: (2021)

Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [(11)C]CB184 and [(11)C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [(11)C](R)-PK11195
por: Hatano, Kentaro, et al.
Publicado: (2015)

Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
por: Folkersma, Hedy, et al.
Publicado: (2011)

Comparison of two different methods of image analysis for the assessment of microglial activation in patients with multiple sclerosis using (R)-[N-methyl-carbon-11]PK11195
por: Kang, Yeona, et al.
Publicado: (2018)

PK11195 Protects From Cell Death Only When Applied During Reperfusion: Succinate-Mediated Mechanism of Action
por: Seidlmayer, Lea K., et al.
Publicado: (2021)

Promise is fulfilled for computer researcher
por: Hawkes, N
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_2cbse398qemuc5ls1edsien69l