Preclinical evaluation of (S)-[(18)F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971

PURPOSE: Positron emission tomography (PET) studies with radioligands for 18-kDa translocator protein (TSPO) have been instrumental in increasing our understanding of the complex role neuroinflammation plays in disorders affecting the brain. However, (R)-[(11)C]PK11195, the first and most widely use...

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Detalles Bibliográficos
Autores principales: Ramakrishnan, Nisha K., Hird, Matthew, Thompson, Stephen, Williamson, David J., Qiao, Luxi, Owen, David R., Brooks, Allen F., Scott, Peter J. H., Bacallado, Sergio, O’Brien, John T., Aigbirhio, Franklin I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712295/
https://www.ncbi.nlm.nih.gov/pubmed/34405276
http://dx.doi.org/10.1007/s00259-021-05495-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712295/
https://www.ncbi.nlm.nih.gov/pubmed/34405276
http://dx.doi.org/10.1007/s00259-021-05495-w

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