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Molecular Identity and Location Influence Purkinje Cell Vulnerability in Autosomal-Recessive Spastic Ataxia of Charlevoix-Saguenay Mice

Patterned cell death is a common feature of many neurodegenerative diseases. In patients with autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and mouse models of ARSACS, it has been observed that Purkinje cells in anterior cerebellar vermis are vulnerable to degeneration while tho...

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Detalles Bibliográficos
Autores principales: Toscano Márquez, Brenda, Cook, Anna A., Rice, Max, Smileski, Alexia, Vieira-Lomasney, Kristen, Charron, François, McKinney, R. Anne, Watt, Alanna J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712330/
https://www.ncbi.nlm.nih.gov/pubmed/34970120
http://dx.doi.org/10.3389/fncel.2021.707857