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Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species

A number of neurodegenerative diseases are associated with the accumulation of misfolded proteins, including Alzheimer’s disease (AD). In AD, misfolded proteins such as tau and amyloid-β (Aβ) form pathological insoluble deposits. It is hypothesized that molecules capable of dissolving such protein a...

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Detalles Bibliográficos
Autores principales: Kaku, Hiroaki, Ludlow, Alexander V., Gutknecht, Michael F., Rothstein, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712662/
https://www.ncbi.nlm.nih.gov/pubmed/34970117
http://dx.doi.org/10.3389/fnmol.2021.750578