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Treatment With Cladribine Selects IFNγ+IL17+ T Cells in RRMS Patients – An In Vitro Study
BACKGROUND: Multiple sclerosis (MS) is an incurable autoimmune disease mediated by a heterogeneous T cell population (CD3+CD161+CXCR3−CCR6+IFNγ−IL17+, CD3+CXCR3+CCR6+IFNγ+IL17+, and CD3+CXCR3+IFNγ+IL17− phenotypes) that infiltrates the central nervous system, eliciting local inflammation, demyelinat...
Autores principales: | Dobreanu, Minodora, Manu, Doina Ramona, Mănescu, Ion Bogdan, Gabor, Manuela Rozalia, Huţanu, Adina, Bărcuţean, Laura, Bălaşa, Rodica |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8712887/ https://www.ncbi.nlm.nih.gov/pubmed/34970256 http://dx.doi.org/10.3389/fimmu.2021.743010 |
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