Improvements in the Tolerability Profile of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods

The development process of antisense oligonucleotides (ASOs) as therapeutic agents in humans has advanced through the implementation of chemical compound modifications as well as increasingly sophisticated toxicological preclinical screening techniques. The Ionis Integrated Safety Database was utili...

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Detalles Bibliográficos
Autores principales: Partridge, Wesley, Xia, Shuting, Kwoh, T. Jesse, Bhanot, Sanjay, Geary, Richard S., Baker, Brenda F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713270/
https://www.ncbi.nlm.nih.gov/pubmed/34242101
http://dx.doi.org/10.1089/nat.2020.0917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713270/
https://www.ncbi.nlm.nih.gov/pubmed/34242101
http://dx.doi.org/10.1089/nat.2020.0917

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