Cargando…

Insights Into the Inhibition of MOX-1 β-Lactamase by S02030, a Boronic Acid Transition State Inhibitor

The rise of multidrug resistant (MDR) Gram-negative bacteria has accelerated the development of novel inhibitors of class A and C β-lactamases. Presently, the search for novel compounds with new mechanisms of action is a clinical and scientific priority. To this end, we determined the 2.13-Å resolut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ishikawa, Tatsuya, Furukawa, Nayuta, Caselli, Emilia, Prati, Fabio, Taracila, Magdalena A., Bethel, Christopher R., Ishii, Yoshikazu, Shimizu-Ibuka, Akiko, Bonomo, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713471/ https://www.ncbi.nlm.nih.gov/pubmed/34970229 http://dx.doi.org/10.3389/fmicb.2021.720036

Ejemplares similares

1250. Novel Boronic Acid Transition State Analogs (BATSI) with in vitro inhibitory activity against class A, B and C β-lactamases
por: Mojica, Maria F, et al.
Publicado: (2020)

Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses
por: Alsenani, Tahani A., et al.
Publicado: (2023)

CMY-1/MOX-family AmpC β-lactamases MOX-1, MOX-2 and MOX-9 were mobilized independently from three Aeromonas species
por: Ebmeyer, Stefan, et al.
Publicado: (2019)

The β-Lactamase Inhibitor Boronic Acid Derivative SM23 as a New Anti-Pseudomonas aeruginosa Biofilm
por: Peppoloni, Samuele, et al.
Publicado: (2020)

1,2,3-Triazolylmethaneboronate: A Structure Activity Relationship Study of a Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase
por: Caselli, Emilia, et al.
Publicado: (2020)

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa
por: Barnes, Melissa D., et al.
Publicado: (2018)

AAI101, a Novel β-Lactamase Inhibitor: Microbiological and Enzymatic Profiling
por: Papp-Wallace, Krisztina M, et al.
Publicado: (2017)

Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase of Acinetobacter baumannii
por: Powers, Rachel A., et al.
Publicado: (2014)

The Effectiveness of Imipenem–Relebactam against Ceftazidime-Avibactam Resistant Variants of the KPC-2 β-Lactamase
por: Papp-Wallace, Krisztina M., et al.
Publicado: (2023)

A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii
por: Hujer, Andrea M., et al.
Publicado: (2021)

Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors
por: Lefurgy, Scott T., et al.
Publicado: (2020)

RNA-hydrolyzing activity of metallo-β-lactamase IMP-1
por: Kato, Yoshiki, et al.
Publicado: (2020)

Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum
por: Powers, Rachel A., et al.
Publicado: (2023)

698. Nacubactam Inhibits Class A β-lactamases
por: Barnes, Melissa D, et al.
Publicado: (2018)

1437. Biochemical characterization of L1 and L2 β-lactamases from clinical isolates of Stenotrophomonas maltophilia
por: Mojica, Maria F, et al.
Publicado: (2020)

1572. Combination Cefuroxime and Sulopenem is active in vitro against Mycobacterium abscessus
por: Dousa, Khalid M, et al.
Publicado: (2020)

Radiative capture on $^{242}$Pu for MOX fuel reactors
por: Guerrero, Carlos, et al.
Publicado: (2013)

New Digital Metal-Oxide (MOx) Sensor Platform
por: Rüffer, Daniel, et al.
Publicado: (2018)

Environmental Engineering Applications of Electronic Nose Systems Based on MOX Gas Sensors
por: Khorramifar, Ali, et al.
Publicado: (2023)

Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane β-Lactamase Inhibitor To Augment β-Lactam Action
por: Dousa, Khalid M., et al.
Publicado: (2022)

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3
por: Kumar, Vijay, et al.
Publicado: (2021)

Cyclic Boronates Inhibit All Classes of β-Lactamases
por: Cahill, Samuel T., et al.
Publicado: (2017)

Will morphing boron-based inhibitors beat the β-lactamases?
por: Krajnc, Alen, et al.
Publicado: (2019)

Population Structure, Molecular Epidemiology, and β-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States
por: Mojica, Maria F., et al.
Publicado: (2019)

Detection of SHV β-lactamases in Gram-negative bacilli using fluorescein-labeled antibodies
por: Hujer, Andrea M, et al.
Publicado: (2009)

2806. The Mechanism of β-Lactam Antibiotic Action: Structural Analysis of Mycobacterium abscessus l,d-Transpeptidases, d,d-Carboxypeptidase and penicillin-binding-proteins binding by imipenem, ceftaroline, and amoxicillin
por: Shin, Eunjeong, et al.
Publicado: (2023)

Consensus on β-Lactamase Nomenclature
por: Bradford, Patricia A., et al.
Publicado: (2022)

Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan
por: Mano, Yoko, et al.
Publicado: (2015)

TREFEX: Trend Estimation and Change Detection in the Response of MOX Gas Sensors
por: Pashami, Sepideh, et al.
Publicado: (2013)

Selective Detection of Hydrogen Sulfide and Methane by a Single MOX-Sensor
por: Shaposhnik, Alexey, et al.
Publicado: (2019)

First biphotochromic fluorescent protein moxSAASoti stabilized for oxidizing environment
por: Marynich, N. K., et al.
Publicado: (2022)

Sulfonamidoboronic Acids as “Cross-Class” Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii
por: Introvigne, Maria Luisa, et al.
Publicado: (2023)

Detecting Changes of a Distant Gas Source with an Array of MOX Gas Sensors
por: Pashami, Sepideh, et al.
Publicado: (2012)

Quantitative Ethylene Measurements with MOx Chemiresistive Sensors at Different Relative Air Humidities
por: Krivec, Matic, et al.
Publicado: (2015)

Fast Measurements with MOX Sensors: A Least-Squares Approach to Blind Deconvolution
por: Martinez, Dominique, et al.
Publicado: (2019)

Real Time Monitoring of Wine Vinegar Supply Chain through MOX Sensors
por: Genzardi, Dario, et al.
Publicado: (2022)

The MoxFo initiative—Mechanisms of action: Biomarkers in multiple sclerosis exercise studies
por: Rosenkranz, Sina C, et al.
Publicado: (2023)

1642. A Novel β-lactamase Inhibitor (Durlobactam, DUR) and β-Lactams Enhance Susceptibility Against Multidrug-Resistant (MDR) Mycobacterium abscessus (Mab)
por: Dousa, Khalid M, et al.
Publicado: (2020)

Safety evaluation of the food enzyme peroxidase from the genetically modified Aspergillus niger strain MOX
por: Lambré, Claude, et al.
Publicado: (2023)

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
por: Brem, Jürgen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dgln5r4mdp6uvpkg4247cst5sf