Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System

Huntington's disease (HD) is one of the most common, dominantly inherited neurodegenerative disorders. It affects the striatum, cerebral cortex, and other subcortical structures leading to involuntary movement abnormalities, emotional disturbances, and cognitive impairments. HD is caused by a C...

Descripción completa

Detalles Bibliográficos
Autores principales: Umek, Tea, Olsson, Thomas, Gissberg, Olof, Saher, Osama, Zaghloul, Eman M., Lundin, Karin E., Wengel, Jesper, Hanse, Eric, Zetterberg, Henrik, Vizlin-Hodzic, Dzeneta, Smith, C. I. Edvard, Zain, Rula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713517/
https://www.ncbi.nlm.nih.gov/pubmed/34520257
http://dx.doi.org/10.1089/nat.2021.0021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713517/
https://www.ncbi.nlm.nih.gov/pubmed/34520257
http://dx.doi.org/10.1089/nat.2021.0021

Ejemplares similares