MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease

Oxidative stress is a major risk factor for Alzheimer's disease (AD), which is characterized by brain atrophy, amyloid plaques, neurofibrillary tangles, and loss of neurons. 8-Oxoguanine, a major oxidatively generated nucleobase highly accumulated in the AD brain, is known to cause neurodegener...

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Detalles Bibliográficos
Autores principales: Mizuno, Yuri, Abolhassani, Nona, Mazzei, Guianfranco, Sakumi, Kunihiko, Saito, Takashi, Saido, Takaomi C., Ninomiya, Toshiharu, Iwaki, Toru, Yamasaki, Ryo, Kira, Jun-ichi, Nakabeppu, Yusaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714343/
https://www.ncbi.nlm.nih.gov/pubmed/34970419
http://dx.doi.org/10.1155/2021/8635088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714343/
https://www.ncbi.nlm.nih.gov/pubmed/34970419
http://dx.doi.org/10.1155/2021/8635088

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