S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for drug-resistant viral variants

We report the in vitro antiviral activity of DZNep (3-Deazaneplanocin A; an inhibitor of S-adenosylmethionine-dependent methyltransferase) against SARS-CoV-2, besides demonstrating its protective efficacy against lethal infection of infectious bronchitis virus (IBV, a member of the Coronaviridae fam...

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Detalles Bibliográficos
Autores principales: Kumar, Ram, Khandelwal, Nitin, Chander, Yogesh, Nagori, Himanshu, Verma, Assim, Barua, Aditya, Godara, Bhagraj, Pal, Yash, Gulati, Baldev R., Tripathi, Bhupendra N., Barua, Sanjay, Kumar, Naveen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714615/
https://www.ncbi.nlm.nih.gov/pubmed/34968527
http://dx.doi.org/10.1016/j.antiviral.2021.105232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714615/
https://www.ncbi.nlm.nih.gov/pubmed/34968527
http://dx.doi.org/10.1016/j.antiviral.2021.105232

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