MTHFR Polymorphism Is Associated With Severe Methotrexate-Induced Toxicity in Osteosarcoma Treatment

BACKGROUND: Previous studies have revealed the critical role of methylene tetrahydrofolate reductase (MTHFR) polymorphisms in response to high-dose methotrexate (MTX)-induced toxicity in osteosarcoma patients. However, the conclusions remain controversial. In this setting, we performed a meta-analys...

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Detalles Bibliográficos
Autores principales: Zhang, Wenchao, Liu, Zhongyue, Yang, Zhimin, Feng, Chengyao, Zhou, Xiaowen, Tu, Chao, Li, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714641/
https://www.ncbi.nlm.nih.gov/pubmed/34976820
http://dx.doi.org/10.3389/fonc.2021.781386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714641/
https://www.ncbi.nlm.nih.gov/pubmed/34976820
http://dx.doi.org/10.3389/fonc.2021.781386

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