Cargando…

MTHFR Polymorphism Is Associated With Severe Methotrexate-Induced Toxicity in Osteosarcoma Treatment

BACKGROUND: Previous studies have revealed the critical role of methylene tetrahydrofolate reductase (MTHFR) polymorphisms in response to high-dose methotrexate (MTX)-induced toxicity in osteosarcoma patients. However, the conclusions remain controversial. In this setting, we performed a meta-analys...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wenchao, Liu, Zhongyue, Yang, Zhimin, Feng, Chengyao, Zhou, Xiaowen, Tu, Chao, Li, Zhihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714641/ https://www.ncbi.nlm.nih.gov/pubmed/34976820 http://dx.doi.org/10.3389/fonc.2021.781386

Ejemplares similares

Effect of Polymorphisms of ABCB1 and MTHFR on Methotrexate-Related Toxicities in Adults With Hematological Malignancies
por: Han, Jian, et al.
Publicado: (2021)

More severe toxicity of genetic polymorphisms on MTHFR activity in osteosarcoma patients treated with high-dose methotrexate
por: Xie, Lu, et al.
Publicado: (2017)

MTHFR variant is associated with high-dose methotrexate-induced toxicity in the Chinese osteosarcoma patients
por: Xu, Leilei, et al.
Publicado: (2018)

A novel necroptosis-related lncRNAs signature effectively predicts the prognosis for osteosarcoma and is associated with immunity
por: Liu, Binfeng, et al.
Publicado: (2022)

A Novel Glutamine Metabolism-Related Gene Signature in Prognostic Prediction of Osteosarcoma
por: Wan, Lu, et al.
Publicado: (2022)

Stem Cell-Laden Hydrogel-Based 3D Bioprinting for Bone and Cartilage Tissue Engineering
por: Yang, Zhimin, et al.
Publicado: (2022)

Identification of cuproptosis-related lncRNA prognostic signature for osteosarcoma
por: Liu, Binfeng, et al.
Publicado: (2022)

Effects of polymorphisms in the MTHFR gene on 5-FU hematological toxicity and efficacy in Thai colorectal cancer patients
por: Atasilp, Chalirmporn, et al.
Publicado: (2022)

The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
por: Shen, Yaqing, et al.
Publicado: (2021)

Molecular characterization of immunogenic cell death indicates prognosis and tumor microenvironment infiltration in osteosarcoma
por: Liu, Zhongyue, et al.
Publicado: (2022)

MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
por: Umerez, Maitane, et al.
Publicado: (2017)

Association of MTHFR and RFC1 gene polymorphisms with methotrexate efficacy and toxicity in Chinese Han patients with rheumatoid arthritis
por: Wang, Shengli, et al.
Publicado: (2019)

MTHFR polymorphism and red cell folate levels are not useful as biomarkers of methotrexate efficacy and toxicity in children with juvenile idiopathic arthritis
por: Tuková, J, et al.
Publicado: (2008)

MTHFR and MTRR Genetic Polymorphism of Methotrexate Therapy Outcomes in Early Rheumatoid Arthritis
por: Zhang, Qian, et al.
Publicado: (2023)

Relevance of MTHFR polymorphisms with response to fluoropyrimidine-based chemotherapy in oesophagogastric cancer: a meta-analysis
por: Zhong, Lei, et al.
Publicado: (2018)

Emerging Applications of Deep Learning in Bone Tumors: Current Advances and Challenges
por: Zhou, Xiaowen, et al.
Publicado: (2022)

Association of MTHFR C677T and A1298C gene polymorphisms with methotrexate efficiency and toxicity in Algerian rheumatoid arthritis patients
por: Berkani, Lilya M., et al.
Publicado: (2017)

MTHFR Gene Polymorphism Association With Psoriatic Arthritis Risk and the Efficacy and Hepatotoxicity of Methotrexate in Psoriasis
por: Zhu, Jie, et al.
Publicado: (2022)

Correlation Analysis Between MTHFR C677T Polymorphism and Uterine Fibroids: A Retrospective Cohort Study
por: Shen, Jiahui, et al.
Publicado: (2021)

The emerging applications and advancements of Raman spectroscopy in pediatric cancers
por: Li, Chenbei, et al.
Publicado: (2023)

Influence of genetic polymorphisms in the folate pathway on toxicity after high-dose methotrexate treatment in pediatric osteosarcoma
por: Park, Jeong A, et al.
Publicado: (2016)

MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate
por: Zhang, Qi, et al.
Publicado: (2022)

Influence of Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphism on High-Dose Methotrexate-Related Toxicities in Pediatric Non-Hodgkin Lymphoma Patients
por: Lu, Suying, et al.
Publicado: (2021)

A Necroptosis-Related lncRNA Signature Predicts Prognosis and Indicates the Immune Microenvironment in Soft Tissue Sarcomas
por: Liu, Binfeng, et al.
Publicado: (2022)

Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions
por: Tang, Jinxin, et al.
Publicado: (2022)

Methotrexate Free Chemotherapy and Limb Salvage Surgery for Paediatric Osteosarcoma in India
por: Sukumaran, Reghu Kesavapillai, et al.
Publicado: (2018)

Folate intake, alcohol consumption, and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism: influence on prostate cancer risk and interactions
por: Kobayashi, Lindsay C., et al.
Publicado: (2012)

Integrated multiomic analysis and high‐throughput screening reveal potential gene targets and synergetic drug combinations for osteosarcoma therapy
por: Zhang, Wenchao, et al.
Publicado: (2023)

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma
por: He, Jieyu, et al.
Publicado: (2021)

Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia
por: Xu, Meng, et al.
Publicado: (2022)

Research hotspots and emerging trends of deep learning applications in orthopedics: A bibliometric and visualized study
por: Feng, Chengyao, et al.
Publicado: (2022)

Patients’ risk factors for periprosthetic joint infection in primary total hip arthroplasty: a meta-analysis of 40 studies
por: Ren, Xiaolei, et al.
Publicado: (2021)

Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis
por: Scheuern, Andrea, et al.
Publicado: (2016)

Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia
por: Liu, Shu-Guang, et al.
Publicado: (2017)

Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients: Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms
por: Lima, Aurea, et al.
Publicado: (2014)

Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population
por: Lv, Shuang, et al.
Publicado: (2018)

MTHFR polymorphisms and breast cancer risk
por: Hosseini, Mojgan, et al.
Publicado: (2011)

Osteosarcoma immune prognostic index can indicate the nature of indeterminate pulmonary nodules and predict the metachronous metastasis in osteosarcoma patients
por: He, Xuanhong, et al.
Publicado: (2022)

MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome
por: Li, Miao-Nan, et al.
Publicado: (2017)

Prognostic and clinicopathologic significance of circZFR in multiple human cancers
por: Liu, Zhongyue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2vbom2ki1ufkug39l7j81dd66d