Establishment of a Dihydrofolate Reductase Gene Knock-In Zebrafish Strain to Aid Preliminary Analysis of Congenital Heart Disease Mechanisms

Background: The dihydrofolate reductase (DHFR) gene is imperative in development, therefore it is essential to explore its effects on heart development. Thus, here a dhfr zebrafish knock-in (KI) strain was constructed. Methods: CRISPR/Cas9 technology was used to establish the dhfr KI zebrafish strai...

Descripción completa

Detalles Bibliográficos
Autores principales: Gong, Ke, Xie, Ting, Yang, Yifeng, Luo, Yong, Deng, Yun, Chen, Kun, Tan, Zhiping, Guo, Hui, Xie, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714833/
https://www.ncbi.nlm.nih.gov/pubmed/34977180
http://dx.doi.org/10.3389/fcvm.2021.763851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714833/
https://www.ncbi.nlm.nih.gov/pubmed/34977180
http://dx.doi.org/10.3389/fcvm.2021.763851

Ejemplares similares