Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway

Our previous study manifested that lanthanum chloride (LaCl(3)) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl(3). Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected....

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Detalles Bibliográficos
Autores principales: Fang, Shanyu, Zhang, Ping, Chen, Xinping, Liu, Fujun, Wang, Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714849/
https://www.ncbi.nlm.nih.gov/pubmed/34977076
http://dx.doi.org/10.3389/fmed.2021.776876
Descripción
Sumario:Our previous study manifested that lanthanum chloride (LaCl(3)) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl(3). Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected. LaCl(3) induced more cell death and apoptosis caused by DDP in two cell lines, accompanied by upregulation of Bax and Cleaved caspase 3 proteins, and downregulation of Bcl-2 protein. LaCl(3) also could decrease RAD51 protein by inactivation of the PI3K/Akt pathway. These data indicated that LaCl(3) could be a potential drug to modulate DDP resistance by inactivating of PI3K/Akt pathway and attenuating DNA repair in ovarian cancer.

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